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Magnetically Recoverable Nano Sulfated Titania Catalysed One Pot Synthesis of 4(3H)-quinazolinone Derivatives

[ Vol. 7 , Issue. 3 ]

Author(s):

Sandip S. Sabale and Mariam S. Degani*   Pages 167 - 175 ( 9 )

Abstract:


Intoduction: A highly efficient protocol for the one pot synthesis of 4(3H)-quinazolinones from anthranilic acid, ortho esters and various amines using a magnetically separable solid acid catalyst, nano sulfated TiO2 encapsulated Fe3O4 with microwave irradiation, is described. The plausible reaction mechanism for the synthesis of 4(3H)-quinazolinone, catalyzed by sulfated TiO2 encapsulated magnetic nanomaterial is also described.

Conclusion: The developed process has been successfully applied for the synthesis of diverse 4(3H)- quinazolinones with variable functionality. This approach overcomes many of the drawbacks of the existing methods and provides an environmentally benign process.

Keywords:

Magnetic nanoparticles, nano sulfated TiO2, solid acid catalyst, quinazolinone, microwave, amines.

Affiliation:

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai- 400019, Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. Parekh Marg, Matunga, Mumbai- 400019



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