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Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using Carboxylic Acids as Catalyst

[ Vol. 7 , Issue. 3 ]

Author(s):

Elham Mir, Ebrahim Mollashahi and Ghasem Marandi*   Pages 217 - 223 ( 7 )

Abstract:


Introduction: A one-pot approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in the reaction between 2-aminobezamide and aromatic aldehydes in the presence of highly available carboxylic acids such as benzilic acid, phthalic acid and salicylic acid has been reported.

Material and Methods: Carboxylic acids such as benzilic acid, phthalic acid and salicylic acid, used as efficient catalysts for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones, are structurally stable compounds. Synthesized compounds were characterized by 1H NMR and IR spectroscopy and their melting points are in good agreement with previous reports.

Results: Results show that carboxylic acids such as benzilic acid, phthalic acid and salicylic can act as effective catalysts in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones without any side products in acceptable reaction time.

Conclusion: In conclusion, we use a simple one-pot process for the synthesis of 2,3- dihydroquinazolin-4(1H)-ones by using carboxylic acids which has some advantages such as low cost, nontoxic solvents and simple separation of products.

Keywords:

Aromatic aldehydes, 2-aminobenzamide, carboxylic acids, 2, 3-dihydroquinazolin-4(1H)-one derivatives, benzilic acid, salicylic acid.

Affiliation:

Department of Chemistry, Faculty of Science, University Sistan and Baluchestan, Zahedan, Department of Chemistry, Faculty of Science, University Sistan and Baluchestan, Zahedan, Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia

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